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35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582 JAPAN

Updates2015~2021　(Please click here for updates in 2014)

NEWS&

International Updates

2021-5 New!
We showed effective systemic oxygenation by intra-colonic injection of oxygenated PFC to apply hypoxia pigs (Doi: https://doi.org/10.1016/j.medj.2021.04.004 ).
2021-2
We have developed the world's first self-intestinal epithelium regenerative therapy which enables the large intestine to perform as the small intestine, recovering the function of the small intestine at the same time. Administering conventional immunosuppressant to patients who underwent the small intestine transplant therapy is subject to the incidence of acute graft rejection. As an alternative therapy for such immunosuppressants, we have developed the self-intestinal epithelium regenerative therapy and have reported its efficacy in the journal Nature (doi: 10.1038/s41586-021-03247-2). By using preclinical pig models, we are researching to further refine this technology with specialists around the world, and hope to offer an option for this therapy to suffering patients in the near future.
2021-2
We have developed a new 8K-UHD digital microscope system with digital zooming to enable maximum 300X magnification of the surgical field. This system has specific lighting settings for shadows dropped in surgical field to expand the three-dimensional effect while still being a monocular camera. The original mechanism and design was shown in the journal of Heliyon.
2021-1
A free online seminar will be held by the International Society for Experimental Microsurgery on January 23, 2021. ’Novel Eye for Microsurgeons’ by Professor Eiji Kobayashi. For those interested in participating in the seminar, please contact Professor Hao Wang by email at: [email protected]
2020-11
We developed a novel assist robot utilizing high‐ precision sensorless haptic technology. The robot adopts a cable‐driven mechanism to maintain a distance from the surgical area and enhances compatibility with surgical equipment such as microscopes.
Development of a microsurgery-assisted robot for high-precision thread traction and tension control, and confirmation of its applicability. Hangai S, Nozaki T, Soma T, Miyashita H, Asoda S, Yazawa M, Sato K, Kawana H, Ohnishi K, Kobayashi E.　Int J Med Robot. 2020 Nov 18:e2205. doi: 10.1002/rcs.2205. Online ahead of print.
2020-6
We are now entering the so-called coronavirus era―an unprecedented situation in which the collaboration of medicine and economy is needed than ever before. The collaborative research articles of Kobayashi lab and the companies are now published.　
In collaboration with Sunarrow Limited We have developed the PVA tube “Lymph” for lymphatic anastomosis practices in supermicrosurgery. “Lymph” was produced by mixing several PVA and then adjusting the temperature and time of frozen cross-linking agent in order to make its texture similar to a lymph vessel of a living body: Kobayashi E, Yamashita S. A training tool for lymphatic vessel anastomosis in supermicrosurgery: An ultrafine polyvinyl alcohol tube. Microsurgery. 2020 Jul 9. doi: 10.1002/micr.30625. Online ahead of print.
By using its unique film processing technology, Sunarrow Limited has succeeded in producing the extremely light and transparent face guards to help the healthcare workers who fight against the COVID-19. (Photo: Professor Mihai Oltean of Sahlgrenska University Hospital, Sweden)
2020-5
With Sysmex, a global manufacturer of clinical testing apparatus: Development of an ex vivo xenogeneic bone environment producing human platelet-like cells. PLoS One. 2020 Apr 7;15(4):e0230507
With SCREEN, a global manufacturer of semiconductors: Development of a simple and active shunt system in the anhepatic stage for surgical training of orthotopic liver transplantation. Transplant Proc. 2020 May 25;S0041-1345(20)30245-1.
2020-2
A new generation microscope (Micro 8) is developed by use of 8K ultra-high-definition video. This information can share through Scandinavian Microsurgery Academy.
2019-11
The 15th SODP(2019 Organ Donation Congress) was held at 14-16 Nov 2019 in Dubai, UAE (http://www.isodp2019.org/). Prof. Kobayashi presented a novel topic of ‘A Portable Hydrogen Gas Filling System to Organ Preservation Solution By Hydrgen Absorption Alley Canister’(https://www.keio.ac.jp/en/press-releases/2019/Oct/2/49-63414/)
2019-10
The 15th Congress of International Xenotransplantation Association was held in Munich, Germany at 10-13 Oct 2019 (http://www.ixa2019.org/). Prof Kobayashi`s group presented their advancements focusing on `the pigs as an in vivo bioreactor for human organs`.
2019-6
Prof Kobayashi had a special lecture in The 4th International Congress of Miniature Pig in Jiangmen, China (26-29, June 2019). He has been working on pig research for medical use (Chinese translation) for a long time.
2019-5
We succeeded the development of an immunodeficient pig model, by surgically removing the thymus and spleen with a combination of triple immunosuppressive drugs ( published on line journal of Nature Communications). This model will be used for clinically relevant evaluation of human cell original products and for In vivo bioreactor for development of human organs.
2018-11
In Transplantation Science Symposium Asian Regional Meeting 2018, Prof. Kobayashi provided an overview of recent research attempts for organ regeneration and introduce future strategies for creating transplantable organs. https://www.tss2018taiwan.org
2018-11
Research in the field of human stem cells has advanced recently; however, it is still difficult to generate the human organoid in vitro. Prof. Kobayashi presented to use a pig as an in vivo bioreactor in which human iPS derived progenitors generate to be mature. ATW 2018 www.atweek.org/01_about/s11.html
2018-9
Tipping the balance toward regulatory T cells (Tregs) through adoptive cell therapy has shown promise to induce transplantation tolerance. Prof Wei’s group, Linkou Chang Gung Memorial Hospital with Prof E Kobayashi successfully showed the behaviors of the transferred Tregs in real-time fashion. (Bioimaging of alloantigen-stimulated regulatory T cells in rat vascularized composite allotransplantation. PLoS One. 2018 Sep 7;13(9):e0203624. doi:10.1371/journal.pone.0203624. eCollection 2018.)
2018-8
In TERMIS-WC2018 (4-7 Aug, Kyoto, Japan), the following papers were presented by Prof. E Kobayashi. 1. Organ-Specific Decellularized Extracellular Matrices from Pigs 2. Pig Spleen as the site of human hepatocyte regeneration. Please visit our website for the final program. http://www2.convention.co.jp/termis-wc2018/pdf/pro_symposia.pdf
In ISEM 2018(23-25 Aug, Debrecen, Hungary), the following papers were presented by Prof. E Kobayashi. www.isem2018.org 　 1. Liver Bud Transplantation in Rats 2. A New Wind For Microsurgery- 3D Video Microscope 3. Robot-Assisted Surgery- A New Wind For Microsurgery. The content of 1 will be published in Magyar Sebészet Those of 2 and 3 are now published in Acta Cir Bras. 2018 Sep;33(9):862-867
2018-7
In TTS 2018 (1-7 July, Madrid), the following papers were presented. 1. Impact of In situ cold perfusion of kidney grafts during vascular anastomosis. by S. Torai et al. 2. New organ transplantation technology for suturing vessels with perusing organs. by S. Yoshimoto et al. 3. Chimeric human liver reconstruction within the spleen of adult pigs. by Prof. E. Kobayashi.
2018-5
Restenosis after catheter or surgical intervention substantially affects the prognosis of arterial occlusive disease.　 Using Luciferase Tg rat, a collaborative study with Tokyo Women's Medical University shows that a cell sheet consisted of mesenchymal stem cells have anti-stenotic effects on injured arteries.
“International Symposium on Bioimaging for the Globalization of New Drug Development”was held at 18th May, 2018 in Konkuk University (Soul, Korea). Prof Kobayashi presented “Firefly Rat: Application for Drug Screening and stem cell research” in the session of “Bioimaging for Approval and Licensing-out”.
2018-4
Attached please find the new spring issue of ISEM Newsletter. Tremendous effort has been made, exciting changes and activities are happening in our Society!!! All in the newsletter, please enjoy!
2018-3
Prof. Kobayashi presented his research strategy for human organ fabrication at Aachan University (19/March/2018, Germany)
2017-11
Prof. Kobayashi presented at AACPRS & CPSSCRC 2017 (Boao China)
2016-06
ISEM 2016 (International Society for Experimental Microsurgery) is to be held in Tianjin, China from August 25-28, 2016.
2016-06
New optimization of experimental mini pigs on feasibility for the developments of drugs, medical devices and products for regenerative medicine
2016-06
Prof. Kobayashi will have a lecture for "Takumi Waza" in Tianjin at the end of August 2016.
2016-06
"Early exposure of operative techniques for future surgeons
-The basics for vascular sutures by microscopes-"
Hands-on Seminar is going to be held in Osaka on June 6th by ISEM West Japan. 30 members can attend the Hands on Seminar on a first-come-first-served basis.
Hands-on Seminar by Prof. Uemoto
2016-04
“The establishment of co-research core for new treatment methodology of (including surgical technique, drug and devices) veterinary medicine”
Prof. Kobayashi has been perusing for the necessity of developing new methodology to cure malignant disease of pets that are regarded as companions for the human patients suffering from incurable diseases through cross-border collaborative relationship among medicine, veterinary and pharmacy faculties. This time the co-research core will be inaugurated at Nippon Veterinary and Life Science University (President Mr. Ikemoto) in Musashisakai Tokyo, JAPAN. Professor Kobayashi as a visiting professor together with the professor Hakamata, School of Veterinary Medicine will verify new therapeutic technology applicable for clinical practices through the generation of experimental animals based on the highly advanced microsurgical techniques. He also has open doors for collaborative corporations in consent of new therapeutic methodology in order to push forward further development of medicine-veterinary relationship and academia-industry co-development project.
2015-11
ISEM West Branch Dispatched Certificate of Attencance and Awarded Best Skill Performing Doctor signed by Profs. Uemoto, Kobayashi and ISEM President Nobert Nemeth with a Letter of Appreciation to the participants in the Hands-on Seminar in Kumamoto, which surely leads to the success of ISEM 2016 in Tianjin, China
2015-10
In Cherished Remembrance of Dr. Sun Lee
2015-10
ISEM 2016 (International Society for Experimental Microsurgery) official website is now available on the Internet.
2015-09
Succeeded in Kidney Organ “Bud” Transplant : Development of “Cloaca Graft”
Prof. Eiji Kobayashi of Keio University School of Medicine in collaboration with Prof. Takashi Yokoo of Jikei University School of Medicine and Prof. Hiroshi Nagashima of Meiji University has developed “Cloaca Graft” and disclosed research results at PNAS (Proceedings of the National Academy of Sciences of the United States of America) on 22nd of September, 2015. The news was broadcast not only for its academic value but as a great advantage for suffering patients from Kidney malfunction.

BBC News: http://www.bbc.com/news/health-34312125?SThisFB

For further details about "Cloaca Graft", please click here.
2015-09
"Firefly" rats connect all the Chinese researchers in regenerative medicine (scene from The 12th Chinese National Congress of Aesthetic and Plastic Surgeon, CDMA held in Shanghai from Aug 28 through Aug 30 2015)
2015-09
Prof. Li and Prof. Kobayashi have been enhancing mutual friendship not only for treating patients but for exchanging research results (Please click here). In line with the renovation of the Shanghai Nineth People's Hospital, Prof. Li inaugurated "Shanghai Plastic and Reconstructive Surgery Institution, Lab of Tissue Regenaration and Fabrication" with the aim of advancing co-researches with Prof. Koayashi. The opening ceremony was held on August 31st 2015. Prof. Koabyashi gave a keynote speech entitled "Why doctors are in need of pushing forward researches?".
2015-07
Prof. Kobayashi's lab dedicated to Organ Fabrication at Keio University School of Medicine has started connecting with researchers on a global scale through Internet
2015-06
Jon Takemoto, Ph.D., Prof. of Biology at Utah State University's visit to our lab
2015-06
ISEM Session at ESSR 2015 Congress was successfully held in Liverpool, UK
2015-06
Letter of Commission to be a Special Advisor to Daegu-Gyeongbuk Medical Innovation Foundation
Domestic Updates
2015-10
ISEM West Branch Hands-on Seminar (Special Workshop in Kumamoto)
2015-09
"Shinanomachi Medical Seminar" with The president Fumimaro Takaku of the Japanese Association of Medical Sciences as an honorable guest lecturer
2015-09
Hands-on Seminar for ISEM Japan Chaper East Branch
2015‐09
The 2nd session of bioimaging mouse will be held on Dec. 2nd at Ravimana Kobe during the Congress of The Molecular Biology Society of Japan. Prof. Kobayashi will make a presentation entitled "The Power of Bioimaging Rat".
2015-08
Prof. Kobayashi's lecture on Organ/Tissue Fabrication has been planned based on the recent research results; on 30th November in Kobe "The strategies for fabricating transplantable human organs". Please click here for further contents of the lecture.
2015-08
Dr. Enosawa and Dr. Nudeshima have joined our team as contract lecturers
2015-08
The Summary of ISEM Japan Chapter, West Branch 1st Semester Activities (Please click the respective session name for further details)
*1st session presentation, *2nd session, *3rd session, *4th session
2015-07
KAA Member Get-together at E.Kobayashi's Lab in the Research Park Building
2015-07
Setting up the sophisticated experimental animal laboratory in conjunction with office function (The co-research with Nippon Medical & Chemical Instruments Co., Ltd.)
2015-07
Two Interesting Seminars were held at Keio University School of Medicine for 2 days in a row
2015-07
HAB Public Symposium for the Longevity of Healthy Intestine"Chou-Jyu"
2015-06
The Power of Bio-imaging Rat! The Research Results with Tokyo Medical and Dental University
2015-06
The Founding of the Laboratory Solely Dedicated to Organ Fabrication
2015-06
The 1st Technical & Educational Training on "In Vivo Imaging" with the Luc Tg RAT for Asia Pacific Berthold Technologies Sales Teams
2015-06
The Summary of ISEM Japan Chapter, East Branch Activities 2014 (Please click the following links for 8 sessions' PP Presentations)
*1st Session presentation, *2nd Session, *3rd Session, *4th Session, *5th Session, *6th Session, 7th Session and 10th Session
2015-05
The inauguration of the Center for Development of Medical Training System at Aizu Medical Center in Fukushima prefecture
2051-05
"Firefly" Rat Connects Researchers on Global Scale through the Contribution to the Visualization of Invisibility!
2015-05
Production of Transplantable Liver Graft by our Hand -Research mind for the chirdren suffering from diseases and their families-
2015-04
Berthold Japan Seminar for In-vivo imaging technology in commemoration of Prof. Eiji Kobayashi's Lab for Organ Fabrication at Keio University School of Medicine on May 21st and 22nd, 2015
2015-04
ISEM West Chapter 2015 Program and 1st Meeting held in Kyoto
2015-04
Succeeded in Revivification of Rat Liver in Hypoxia due to Cardiac Arrest
2015-04
The Innovative Therapy Method Development for Regenerating Organs in vivo -Direct Reprogramming-
2015-03
Meiji University: New Models for Organ Production and Transplantation
2015-03
A Positive Spiral of Surgical Education & Reseach by Experimental Microsurgery from ISEM West Branch 2015
2015-03
My Pesonal View on Pig Training Center Project at Veterinary Collages in Japan
2015-02
Suggestions for the ideal role of medical banking system in Japan
2015-02
Exprimental Medicine: A Platform for Cooperation beween Medicine and Veterinary
2015-02
The development of surgical training materials from sacrificed experimental pigs; The co-research with Aizu Medical Center in Fukushima
2015-01
For those who challenge to study medcine
2015-01
The hisotory of world-first agonist medicine development with S1P receptor functions
2015-01
Yamaton K Project: in collaboration with Jikei Medical University & Meiji University


35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582 JAPAN

TEL 81-3-5315-4090
FAX 81-3-5315-4089